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pentobarbital will lessen the level or influence of diazepam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Powerful or average CYP3A4 inducers may enhance price of diazepam elimination; hence, efficacy of diazepam may very well be decreased.pentobarbital will decrease the level or effect of buprenorphine